- Department of Ecology and Evolution
Institute for Genomics and Systems Biology
KCBD Room 10240D
900 E. 57th St.
Chicago, IL, 60637
I am interested in the genetic basis of regulatory evolution. I am focused primarily on understanding the evolution of complex cis-regulatory elements, which integrate multiple inputs from transcription factors and histone modifications to create intricate patterns of time- and tissue-specific gene expression. I am approaching this question from two distinct angles: 1) I am analyzing histone modifications within Drosophila using ChIP-seq. I aim to better comprehend how evolution can alter the complex patterns of histone modifications like H3K27me3. 2) I am studying interactions between transcription factors bound to the DNA, focusing on how novel TF-TF interactions can be gained and lost throughout evolution.
Robert K. Arthur, Lijia Ma, Matthew Slattery, Rebecca F. Spokony, Alexander Ostapenko, Nicolas Négre, Kevin P. White. 2013. Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification. (in press)
Matthew Slattery*, Lijia Ma*, Rebecca F. Spokony*, Robert K. Arthur, Pouya Kheradpour, Anshul Kundaje, Nicolas Nègre, Alex Croft, Ryan Ptashkin, Jennifer Zieba, Alexander Ostapenko, Sarah Suchy, Alec Victorsen, Nader Jameel, A. Jason Grundstad, Wenxuan Gao, Jennifer Moran, E. Jay Rehm, Robert L. Grossman, Manolis Kellis, and Kevin P. White. 2013. Diverse patterns of genome-wide DNA targeting by transcriptional regulators in Drosophila melanogaster. (in press)
Robert K. Arthur and Ilya Ruvinsky. 2012. Evidence that Purifying Selection Operates on Promoter Sequences. Genetics189(3):1121-6.