- Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry
- Does the brain listen to the gut?
- (Meta)genomic insights into the pathogenome of Cellulosimicrobium cellulans
- A robust adaptive denoising framework for real-time artifact removal in scalp EEG measurements
- Imputing Gene Expression in Uncollected Tissues Within and Beyond GTEx
- Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break
- Controlling the Cyanobacterial Clock by Synthetically Rewiring Metabolism
- Choosing experiments to accelerate collective discovery
On the cover of the December Cell Systems issue, IGSB Faculty member Savas Tay, and others, observe that when NF-κB oscillations are entrained by periodic tumor necrosis factor (TNF) inputs in experiments, NF-κB exhibits jumps between frequency modes, a phenomenon called “cellular mode-hopping.” By comparing stochastic simulations of NF-κB oscillations to deterministic simulations conducted inside and outside the chaotic regime of parameter space, they show that noise facilitates mode-hopping in all regimes. The full article can be read here.
Watch UChicago’s Jack Gilbert and Julie Bubeck Wardenburg weigh in on whether probiotics are truly good for you in the latest video from Argonne’s Microbiome Project series here.
The Mary Kay Foundation has awarded IGSB Faculty member Ray Moellering with the Cancer Research Grant to support his work in precision imaging diagnostics in order to detect and target metastatic progression in breast and ovarian cancer.
Of all the possible experiments available in biomedical research, only a small subset are ever tackled by scientists. This is in part due to institutional and cultural pressures that lead researchers to avoid risk-taking and choose inefficient research strategies, according to a new study based on a computational analysis of millions of patents and research articles. Despite increased opportunities for groundbreaking experiments, most scientists choose conservative research strategies to reduce personal risk, which makes collective discovery slower and more expensive, conclude Andrey Rzhetsky, PhD, professor of medicine and human genetics and director of the Conte Center for Computational Neuropsychiatric Genomics, and his colleagues.
Two distinguished scientists and educators have been named fellows of the American Association for the Advancement of Science (AAAS) for their scientifically or socially distinguished efforts to advance science or its applications. The latest University of Chicago additions are Barry Aprison, PhD, a senior lecturer in the Biological Sciences Collegiate Division and education and outreach director for the Institute for Genomics and Systems Biology, and Michael W. Vannier, MD, professor emeritus of radiology.